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News

CLINICIP aims to optimize tight glycaemic control

B.Braun Melsungen : 09 October, 2007  (New Product)
The European CLINICIP research project is aiming to develop a method to improve glycaemic control in intensive care.
The project also is looking to provide a low-risk monitoring and control system that maintains metabolic control of critically ill patients.

Increased blood glucose levels is not just a problem associated with patients that have a history of diabetes. Hyperglycaemia and insulin resistance are also common in critically ill patients.

'Recent medical studies have shown that strict glycaemic control and the implementation of an intensive glucose management protocol have contributed to reduce mortality and morbidity and shortened the length of patient stays in the ICU,' states Dr Martin Ellmerer, scientific coordinator of the CLINICIP project,
Medical University of Graz.

To date, however, the control process has had to be carried out manually which is a time-consuming method, and one that puts great responsibility on the nursing staff. Nurses have to make intuitive decisions about insulin dosages and face the prospect of putting their patients at risk of hypoglycaemia.

'An adaptive control algorithm integrated into a system solution as it is being developed by the CLINICIP project team will reduce the workload and increase the safety and efficiency of insulin therapy. There is a great need for this solution in hospitals worldwide,' says Dr Ellmerer.

Thirteen partners from seven European countries have been working together on this project, mainly with scientific or medical background such as the University of Cambridge, Katholike Universiteit Leuven, Charles University Prague, Medical University of Graz or the Royal Brompton Hospital London as well as industrial partners such as B.Braun, who will use the project findings in the company’s product design.

The decision support system will be able to record therapy data, display trends and suggest insulin doses. It will also offer intelligent alarm monitoring. The idea is to optimize the insulin therapy through an integrated control algorithm which automatically calculates the optimum insulin rate and suggests the time for the next glucose measurement. The system issues an automatic warning as soon as this measurement procedure must be carried out manually. Infusion data from enteral and parenteral nutrition pumps which are influencing the insulin rate calculated by the control algorithm will also be taken into account automatically.

'We are currently in the feasibility study phase with a prototype, and we are optimistic that we will be able to provide the system in the foreseeable future, as we can count on the technology of our intelligent B. Braun Space infusion system. This platform is the essential basis for a challenging therapy like tight glycaemic control in the daily clinical routine,' explains Dr Doris Rothlein, senior scientific manager at B. Braun.

'The CLINICIP project is a perfect example of how clinicians, scientists and the industry can work together productively for the benefit of patients'.

The partners in the CLINICIP project include: B Braun Melsungen, Institute of Spectroscopy Dortmund, University of Cambridge, Royal Brompton Hospital London, Katholieke Universiteit Leuven, SensLab, Charles University Prague, Gambro Dialysatoren, RocheDiagnostics, Medical University of Graz, Joanneum Research, Institute of Applied Physics Florence
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