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News

New therapeutic for stroke patients is licensed

Cardium Therapeutics : 22 October, 2007  (New Product)
Cardium Therapeutics and its subsidiary InnerCool Therapies has entered into a license agreement with the University of Texas Health Science Center at Houston for the clinical research, development and commercialisation of Caffeinol as a potential therapeutic for use in acute ischemic stroke patients.
safety and efficacy of treating stroke patients with Caffeinol, administered by intravenous infusion (IV), in combination with InnerCool's endovascular hypothermia technology. A study has been proposed to the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH).

James C Grotta, MD, director of the Stroke Program and Professor of Neurology at the University of Texas Medical School at Houston, described the need for an effective stroke therapy and the potential of the new technology. 'Within hours of an ischemic stroke, neurotoxic events are triggered in the ischemic brain that result in tissue damage even after blood flow has been restored, which leads to negative outcomes for stroke patients. Caffeinol and hypothermia have both been shown to be beneficial in reducing damage to brain tissue following stroke, and our data suggest that combining these neuroprotective therapies can substantially reduce neurotoxic events triggered by ischemia and allow for better tissue viability and ultimate function. We look forward to working with Cardium and InnerCool in furthering these promising new therapeutic approaches to stroke.'

'Despite the use of thrombolytic drugs such as tissue plasminogen activator or tPA and improved clot retrieval devices, stroke is now the third most prevalent cause of death among adults in the United States and is the leading cause of serious long-term disability,' stated Christopher J Reinhard, chairman and chief executive officer of Cardium Therapeutics and InnerCool Therapies.

'There is clearly a critical need for new means of addressing this major medical condition and this licensing agreement with the University of Texas, together with financial support from the NIH, will allow us to further explore the safety and efficacy of both Caffeinol and hypothermia as potential treatments for ischemic stroke patients. InnerCool's slender flexible metallic catheter, which has a fully integrated temperature sensor, has the potential to rapidly and safely cool patients following ischemic injury and potentially preserve tissue and function in the brain. Data from the ongoing NIH-sponsored ICTuS-L trial has provided excellent evidence of the safety of InnerCool's temperature modulation system in acute ischemic stroke patients and the new ICTuS-C trial is expected to expand that database and further evaluate both cooling and Caffeinol as potential new treatment paradigms for stroke.'

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