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BSD Medical filess a patent smart non-invasive chemotherapy tool

BSD Medical : 19 June, 2007  (New Product)
BSD Medical has filed a patent for a new non-invasive phased array breast treatment applicator that selectively heats breast cancer tumours.
This novel capability is applicable to the 915MHz operating frequency of the BSD-500 hyperthermia system.

The company discovered through research that at 915MHz the characteristics of breast tumours 4 to 5cm in diameter (those typically treated with radiation and/or chemotherapy) selectively absorb microwave energy, while the microwaves largely pass through the other tissues of the breast. The discovery of this selective heating capability could be used in numerous ways for better delivery of hyperthermia in treating breast cancer.

However, one of the novel applications is to use selective heating of breast tumours to release tiny heat-triggered capsules of chemotherapy drugs as they enter breast tumours through the blood stream, causing the capsules to burst inside the tumour, greatly multiplying the potency of the drug delivery.

In this case the breast applicator would serve as the 'targeting system' to find and heat tumours and the heat-triggered drug capsules would become 'smart bombs' that release when heated as they enter the tumour.

Duke University is already using BSD Medical's hyperthermia equipment to release chemotherapy drugs delivered in heat-triggered capsules, and one of the reasons for this new applicator development was to further support Duke's research already underway.

This method of providing chemotherapy thus far has shown the ability to deliver 30 times more drug than would normally reach the tumour site with non-encapsulated drug.

In addition to releasing the chemotherapy capsules, heat (hyperthermia) therapy makes the tumour's blood vessels porous so that the capsules can pass from the bloodstream into the tumour.

Hyperthermia also increases oxygen levels within tumours, and oxygen is critical to the proper functioning of certain chemotherapy agents.

Hyperthermia also amplifies the level of genetic damage that chemotherapy inflicts on cells by inhibiting enzymes that normally repair the damage.

Breast cancer tumours that reach a diameter of 4cm or larger are commonly treated by radical breast removal.

An important objective of this effort is to provide less invasive alternatives for treatment.
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