Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Analysis, Inspection and Laboratory
LeftNav
Assisted/Independent Living
LeftNav
Clinical and Nursing Equipment
LeftNav
Design and Manufacture of Medical Equipment
LeftNav
Diagnostics Equipment, Monitoring and Test
LeftNav
Education, Training and Professional Services
LeftNav
Health Education and Patient Management
LeftNav
Health Estates Management
LeftNav
Healthcare Support and Information Services
LeftNav
Hygiene and Infection Control
LeftNav
IT and Communications in Healthcare
LeftNav
Materials
LeftNav
Medical Device Technology
LeftNav
Research and Development
LeftNav
Safety and Security
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Health Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
News

Buffer screening instrument improves university research

Avacta Analytical : 18 March, 2014  (Application Story)
Students at Manchester University are being encouraged to introduce buffer screening in their biomolecular analysis projects
Buffer screening instrument improves university research


Avacta’s Optim protein stability analysis technology is helping researchers at Manchester University to approach buffer selection in an entirely new way. Dr Tom Jowitt, Manager of the University’s Biomolecular Analysis Core Facility, explained: “Academic institutions tend to work by word of mouth on protein projects, sticking to buffer conditions they are familiar with, or that have been used on previous projects within the laboratory. The buffers in use are often far from optimal for the protein of interest, but a lack of understanding of how to optimise buffer conditions means that these issues are rarely addressed.”



“As proteins become easier and easier to make in large quantities, we are trying to promote the concept of buffer screening, encouraging researchers to spend some time optimising buffer conditions at the start of each project, and this is where Avacta’s Optim instrument comes in. Due to the low sample volume required for each analysis, the Optim system makes it easy to screen a wide range of buffer conditions relatively quickly and cheaply. We can now screen 10 or 20 buffer conditions for a protein of interest in a short space of time, which simply wasn’t plausible before we had the instrument, as the time and labour involved in performing multiple measurements using different technologies for each set of buffer conditions would have been prohibitive. This simple optimisation process can have quite a significant impact on protein stability and aggregation rates, particularly for difficult to handle proteins such as those within extracellular matrix. Thanks to the Optim system, the benefits of buffer screening are being widely recognised throughout the Department and, with approximately 250 research groups, the potential knock-on benefits could be highly significant.”


Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 ProHealthServiceZone.com
Netgains Logo