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News

Carestream releases new large Stokes shift dyes for fluorescent in vivo imaging applications

Carestream Health : 07 September, 2007  (New Product)
Carestream Molecular Imaging, a division of Carestream Health, has introduced new large Stokes shift dyes for fluorescent in vivo imaging applications to its Kodak X-Sight Imaging Agent range.
Kodak X-Sight Large Stokes Shift Dyes are novel, reactive dyes that leverage 50 years of Kodak Dye chemistry expertise. They enable researchers and scientists to maximise the fluorescent signal while minimising auto-fluorescence issues during in vivo imaging.

Kodak X-Sight Imaging Agents along with Kodak In-Vivo Imaging Systems and other products are currently being shown at the Joint AMI/SMI Molecular Imaging Conference in Providence, Rhode Island, USA.

'Our new Kodak X-Sight Large Stokes Shift Dyes, characterised by near infrared emission and a large Stokes shift, enable researchers to achieve a higher sensitivity of fluorescent detection deeper into tissue,' said Shahram Hejazi, PhD, president of Carestream Molecular Imaging. 'With superior performance when compared to other commercially available products, these new dyes validate our outstanding dye chemistry expertise and leadership in fluorescent imaging.'

‘Stokes shift’ refers to the separation of absorption and emission maxima. Having a significantly larger Stokes shift - greater than 80nm in the case of Kodak X-Sight Dyes - helps researchers eliminate much of the background that typically obstructs the
fluorescent signal while allowing researchers to excite and emit the dyes at their maxima, thus resulting in far greater signal to noise. Most commercially available dyes typically have a Stokes shift between 20-30nm.

In an organism, the Kodak X-Sight Dyes can illuminate a region of interest when excited by the appropriate wavelength of fluorescent light, thus allowing the researcher to visualise their target. While the Kodak X-Sight Imaging Agents have been optimised for Kodak Image Station and In-Vivo Systems, they are also compatible with other commercially available digital imaging systems.

Kodak X-Sight Dyes will be available during autumn 2007 for preclinical use.
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