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Clinical data shows medical device increases Hepatitis-C cure rates

Aethlon Medical : 26 March, 2009  (New Product)
New clinical data supports the advancement of the Aethlon Hemopurifier as an adjunct therapy to increase Hepatitis-C (HCV) cure rates.
The Hemopurifier is a first-in-class medical device that assists the immune response in combating infectious disease through real-time therapeutic filtration of infectious viruses and immunosuppressive proteins. In HCV care, the device inhibits viral replication through selective elimination of HCV in circulation and assists to preserve immune cells by removing toxic proteins shed from the surface of HCV.

Data resulting from over 20 HCV treatments indicates an average viral load reduction of 41 percent during each four-hour Hemopurifier treatment.

In the studies, average pre-treatment viral load of 22,868,000 HCV virus copies/ml blood (cpm) was reduced on average by 9,300,000 cpm during the course of each treatment. Based on this data, Aethlon predicts that short-term continuous Hemopurifier treatment can reduce viral load to low to undetectable levels, thus improving the likelihood that HCV patients achieve a sustained virological response (SVR) from the current interferon-ribavirin standard of care and other candidate therapies. HCV infection is considered cured when SVR extends beyond six months.

At present, less than 50 percent of HCV patients respond to interferon-ribavirin therapy. Additionally, there is a direct correlation between low viral load at onset of interferon-ribavirin therapy and increased cure rates. Based on data analysed from each four-hour Hemopurifier treatment, Aethlon projects that a patient with a high viral load of 7 million iu/ml would be reduced to undetectable HCV levels after approximately three days of continuous Hemopurifier treatment. This corresponds to a 4.06 log reduction or an 11,000-fold decrease in viral load. An HCV patient with a moderate viral load of 2 million iu/ml would be projected to reach undetectable levels in approximately 2.5 days of continuous treatment.

All of the studies were conducted in health compromised HCV infected patients who suffer from end-stage renal disease (ESRD) requiring regular kidney dialysis treatment. In these treatment studies, the Hemopurifier inhibited the progression of HCV infection in ESRD patients when included during dialysis treatment administered thrice weekly for four-hours.

The studies were conducted at the Fortis Hospital in Delhi, India.
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