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News

Clontech plans to release new protein expression solution based on Stanford University technique

Clontech Laboratories : 29 January, 2008  (New Product)
Clontech Laboratories plans to release its ProteoTuner systems, which are based on work by researchers at Stanford University, regulate the amount of protein of interest present in a cell, quickly and directly.
The new technique, which Clontech has licensed from Stanford, enables direct manipulation of the in vivo level of a specific protein of interest, making it a powerful tool for analysing protein function. Because the system has low toxicity, it is also suitable for animal studies.

'As a long-standing leader in the field of gene expression control, Clontech is proud to add the ProteoTuner systems to its extensive collection of gene and protein control systems, which include the Tet-On Advanced and Tet-Off Advanced Inducible Gene Expression systems for gene expression control and the Knockout RNAi systems for mRNA knockdown.

Each of these three systems has particular, complementary strengths: the tight regulation of the Tet systems, Knockout RNAi's control of endogenous protein levels, and the fast control of protein levels via the ProteoTuner systems. Each can be used independently or combined to enable exquisite control over protein expression,' said Carol Lou, general manager of Clontech Laboratories.

Clontech's ProteoTuner systems have broad applications in basic and applied research. The fast kinetics of protein stabilisation/destabilisation make it possible to study transient effects of the protein of interest that might otherwise have been masked. The ability to directly control the level of functional protein also makes this technology an unprecedented tool for dissecting the roles of multifunctional proteins, by directly and specifically ‘tuning’ the level of a protein of interest in the cell.

The ProteoTuner systems offer a new resource: the ability to directly regulate protein levels without affecting the normal translational and transcriptional activities of the gene of interest.

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