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New in vivo imaging solution detects single cancer cells

Caliper Life Sciences : 16 April, 2008  (New Product)
Caliper Life Sciences has introduced Bioware Ultra cell lines, a range of ultra bright light producing tumour cell lines created specifically for in vivo imaging applications.
Bioware Ultra cell lines are 10 to 100 times brighter than cell lines created using traditional methods, which allows researchers, for the first time ever, to detect a single cancer cell in an animal via non-invasive in vivo imaging.

Visualising and tracking tumour progression in vivo is critical to better understanding how therapeutic treatments impact disease. In vivo imaging provides researchers with the ability to recognize tumour growth and behaviors at the cellular level within living animals.

By tagging a tumour with the gene for luciferase, the same gene that allows a firefly to glow, the tumour can produce light that can be monitored using Caliper's highly sensitive IVIS imaging systems.

As the disease progresses and reacts to specific compounds, researchers can measure tumour growth and evaluate the efficacy of compounds in real time. This ability to track disease progression in vivo offers a more conclusive understanding of how potential drugs will react in and impact humans.

Increasing the brightness of tumour producing cell lines significantly improves researchers' ability to monitor early tumour behaviour and detect micrometastases sooner. Caliper's Bioware Ultra light producing cell lines incorporate the enhanced luc2 gene from Promega. The luc2 gene, an optimised version of luciferase for expression in mammalian cells, creates intensified visible light allowing more sensitive non-invasive detection of cells in vivo.

Bioware Ultra cell lines offer the most sensitive way to non-invasively examine tumour cell growth in vivo, far exceeding the capabilities of previously available cell lines.

'The ability to detect and monitor a single cancerous cell in an animal model dramatically improves the ability to understand disease evolution from early stages and reaction to treatment options,' said Mark Roskey, vice president, reagents and applied biology, Caliper Life Sciences. 'Previously, oncology researchers needed to tag nearly 500 cells before a sufficient signal could be monitored using optical imaging. Bioware Ultra cell lines are the only line of cells available that offers the research community the level of sensitivity to detect a single cell further demonstrating Caliper's commitment to increasing the capabilities of pre-clinical, non-invasive in vivo imaging.'

Caliper Life Sciences has launched seven Bioware Ultra cell lines covering a range of cancer models, including breast, colorectal, lung and prostate as well as lymphoma. Available immediately, the Bioware Ultra cell lines express on average 1000 photons/sec/cell.

The intense brightness facilitates research efforts to measure tumour growth before tumours are palpable, study tumours from very early stages when a small number of cells is present and to detect micrometastatic events. Bioware Ultra cell lines are optimal for studying variety of xenograft models including orthotopic models in mice and are confirmed to be pathogen free.

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