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News

New Thermo Scientific benchtop LC-MS system suits compound screening applications

Thermo Fisher Scientific Mass Spectrometry : 29 May, 2008  (New Product)
The Thermo Scientific Exactive, a new benchtop LC-MS system designed for compound screening and identification applications, is to be launched at ASMS 2008.
Exactive makes use of proven mass analyser technology from the LTQ Orbitrap platform, the recognised standard for accurate mass and high resolution measurement, to provide precise and confident information. The system is fast, easy-to-use and cost effective to operate, making it an ideal instrument for non-experts in routine analytical laboratories.

'Orbitrap technology has been an important driver of LC-MS growth in the world of biology,' noted Ian Jardine, vice president of global research and development at Thermo Fisher Scientific. 'We asked ourselves what we could do to fully realise the potential of this technology, to make it even more accessible to users with routine toxicology, environmental and drug development workflows. The result is an instrument that we consider a real breakthrough, that can be applied to a great number of challenging new applications.'

The Thermo Scientific Exactive LC-MS streamlines many of the technical steps that normally require specialised set up and operation. An intuitive software interface makes the system easy-to-use in both expert and ‘walk-up’ mode, while ensuring precise mass identification of target compounds over a wide concentration range.

While simple to operate, Exactive sets new standards for LC-MS performance, at resolutions of up to 100,000. When combined with excellent single scan mass accuracy in positive and negative modes, Exactive becomes an ideal system for common screening and high-throughput applications.

'Mass accuracy plays a critical role in reducing analysis times and increasing confidence even in routine measurements,' noted Dr Jardine. 'Co-eluting compounds in complex matrices can be screened and confirmed in a single experiment simply by re-analysing data at a higher resolution. For screening of isobaric compounds that differ by only a few milli-mass units, this accurate mass capability will be of enormous value.'

The Exactive LC-MS system will be unveiled on the Thermo Scientific booth 41 at the 56th ASMS Conference on Mass Spectrometry and Allied Topics, in Denver, USA, June 1 to 5, 2008.
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