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News

Preclinical research study describes benefits of organ regeneration option

Tengion : 16 June, 2008  (Company News)
Tengion has unveiled the results of a preclinical research study conducted with its Neo-Bladder Augment.
The key findings of the preclinical trial - in which either a Tengion Neo-Bladder Augment or a biodegradable mesh scaffold alone was surgically implanted following partial, trigone-sparing cystectomy and both groups were evaluated clinically at one, three, six and nine months - show that the Tengion Neo-Bladder Augment restored baseline urodynamics as early as six months after implantation and led to a structurally and functionally complete regenerated bladder wall as early as nine months.

In contrast, scaffold implants alone failed to return to urodynamic baseline by the study termination and failed to regenerate a complete bladder wall.

'We continue to see great promise in our neo-bladder research programmes and these latest data underscore the potential of Tengion's Autologous Organ Regeneration Platform to provide a neo-organ that allows the body to regenerate a functional organ,' said Dr Bertram, senior vice president, Science and Technology of Tengion. 'We are looking forward to formally sharing these findings with our peers and continuing to develop our Neo-Bladder Augment and the Tengion Neo-Bladder Replacement to meet the critical patient needs that exist today.'

The study will be featured in the July issue of the Journal of Urology, Vol. 180. The paper, ‘Early Cellular and Stromal Responses in Regeneration Versus Repair of a Mammalian Bladder Using Autologous Cell and Biodegradable Scaffold Technologies’, was co-authored by Tengion scientists Manuel J Jayo, DVM, PhD, Deepak Jain, PhD, Belinda J Wagner, PhD and Timothy A Bertram, DVM, PhD.
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