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News

PressureWire yields accurate assessment of translesion pressure gradients

Radi Medical Systems : 31 March, 2008  (New Product)
Use of a low profile PressureWire yields a more accurate assessment of translesion pressure gradients when compared to catheter-derived pressure gradient (CPG) measurements, according to a paper published in the Journal of Interventional Cardiology (2008; Vol. 20, Issue 1: 63-65).
The authors report that although CPG measurements derived from both a Catheter and PressureWire correlated with anatomic stenosis, PressureWire gradient was more accurate in estimating the clinical significance of peripheral arterial lesions, thus reducing the risk of inappropriate intervention. The paper was based on a study of 20 lesions in 16 patients undergoing angiography for peripheral vascular disease.

Entitled ‘Physiologic Evaluation of Translesion Pressure Gradients in Peripheral Arteries: Comparison of PressureWire and Catheter-Derived Measurements’, this study, conducted at the Beth Israel Deaconess Medical Center in Boston, USA, is the first to assess the hypothesis in patients with peripheral arterial occlusive disease.

'We've long suspected that using a 4 or 5 French Catheter for measuring pressure gradients would create artifact, simply due to its size relative to the lumen of the vessel,' stated Lawrence Garcia, MD, principal investigator. 'This study provides confirmation. In 100 percent of the lesions, the PressureWire provided a better physiologic assessment of the pressure gradient, without the interference of the obstruction due to the catheter.'

'Due to its small size, just 0.014, and high-fidelity transducer, PressureWire is able to provide results that are far more accurate than those obtained from Catheter based systems,' said Jim Archetto, chief operating officer for Radi Medical Systems. 'The Beth Israel study findings are consistent with data from other trials utilising PressureWire. Once again the data documents PressureWire as the most accurate diagnostic tool for assessing lesion severity.'

Using this low profile PressureWire for arterial pressure measurement yields a more accurate assessment of renal artery stenosis (RAS) and translesion pressure gradients (TPG), than other methods, according to a similar study published in the European Heart Journal (2008; Vol. 29, 517-524) and the Journal of Interventional Cardiology (2008; Vol. 20, Issue 1: 63-65).

Entitled ‘Assessment of renal artery stenosis: side-by-side comparison of angiography and duplex Ultrasound with pressure gradient measurements’, this study of 56 RAS patients reports that diagnoses based on renal angiography and colour duplex Ultrasound overestimated the severity of RAS by 38 percent and 55 percent compared with those based on a ratio of distal renal pressure to aortic pressure. The paper, authored by Dr Benny Drieghe, also concluded that this overestimate was likely the cause of disappointing results of renal angioplasty for renovascular hypertension.
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