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News

Protein tomography study pinpoints SV2A molecular mechanism

Sidec : 10 September, 2008  (Company News)
Sidec has together with UCB published the first direct structural evidence of the molecular mechanism of the Synaptic Vesicle protein 2A (SV2A) in mouse brain tissue.
SV2A is the brain-binding site of the second generation anti-epileptic drug levetiracetam. The result shows the first direct structural proof of the Ďalternating access model’ that has been proposed for the MFS class of transporter proteins.

The Ďalternating access model’ postulates that the trans-membrane MFS class proteins can exist in two different conformations; as a valve that can be open to either side of the membrane. Prior to the Protein Tomography study, a number of efforts were made to prove this mechanism both by X-ray crystallography and indirectly by site directed mutagenesis.

'Obtaining structures of trans-membrane proteins is notoriously difficult, and the success of such endeavours is difficult to predict. This study demonstrates that Protein Tomography is well adopted to study structure, function and flexibility of trans-membrane proteins,' said Anders Aberg, chief scientific officer at Sidec.

The publication is available on-line in the journal Biochemical and Biophysical Research Communications, August 7, 2008. http://www.elsevier.com/locate/ybbrc
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