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Randox unveils new non-invasive test for early detection of colorectal cancer

Randox Laboratories : 23 October, 2007  (New Product)
Randox Laboratories has developed a new patient friendly test for the detection of mutations associated with colorectal cancer.
The test allows the analysis of DNA in stool samples without the need for dietary or medication changes.

As many as 90 percent of colorectal cancers can be cured if caught at an early stage. Early diagnosis is essential for improvement of patient prognosis in colorectal cancer and screening programmes have already been implemented throughout Europe utilising Faecal Occult Blood tests (FOBt), where positive FOBts are followed by colonoscopy. However, although FOB testing is non-invasive and inexpensive, it suffers from low sensitivity and specificity and results in up to 50 percent of colonoscopies being performed on patients unnecessarily.

Low patient compliance for colonoscopy and the requirement of a surgeon to perform the procedure mean that an intermediate test method for the detection of colorectal cancer would be beneficial.

Chromosomal instability accounts for 85 percent of sporadic colorectal cancers. The ability to screen for point mutations from this pathway using the Randox test in a patient presenting with a positive FOBt provides a valuable aid to the screening process by offering a highly specific test that may also benefit from increased patient compliance.

The DNA array from Randox allows the detection of 28 mutations associated with the chromosomal instability pathway. The new test will increase early detection of both cancer and precancerous lesions and reduce the incidence of mortality associated with colorectal cancer.

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