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News

Survey indicates improved effect on quality of life is one of the greatest unmet needs of COPD patients

Decision Resources : 22 May, 2013  (Company News)
Decision Resources finds that surveyed US and European pulmonologists agree that therapies offering a greater effect on quality of life is among the areas of highest unmet need.


Given the high level of subjectivity and variability of tests used to measure quality of life, interviewed thought leaders state that it is difficult to differentiate therapies based on these measures. However, available clinical data and thought leader opinion indicate that the two sales-leading COPD therapies, Boehringer Ingelheim/Pfizer's Spiriva and GlaxoSmithKline's Advair/Seretide/Adoair, offer comparable efficacy on this attribute. Phase III data indicate Novartis' indacaterol/glycopyrronium may offer greater improvement in quality of life compared with these market leaders.



The DecisionBase 2013 report entitled 'Chronic Obstructive Pulmonary Disease: What Gains in Efficacy Will Be Necessary to Meet Pulmonologist and Payer Expectations for Emerging LABA/LAMAs, LABA/ICSs, and MABAs?' finds that surveyed US pulmonologists would prescribe indacaterol/glycopyrronium to 25 percent of their COPD patients, driven by the robust Phase III efficacy data. However, Decision Resources forecasts that indacaterol/glycopyrronium will earn a more conservative patient share, constrained in part by a late launch relative to its competitors in the USA.



"Phase III data indicate that indacaterol/glycopyrronium has a strong efficacy profile," said Decision Resources Analyst Amanda Puffer. "Thought leaders are enthusiastic about the LABA/LAMA products and expect them to provide greater efficacy compared with individual current therapies. Based on lung function data and improvements in quality of life, indacaterol/glycopyrronium has advantages over both Spiriva and Advair. But the market is expected to be crowded, so we are conservative in our expected uptake of indacaterol/glycopyrronium."



The report also finds that surveyed US managed care organization (MCO) pharmacy directors are not likely to reimburse premium-priced therapies offering improvements in only dosing burden over current treatment regimens. Pharmacy directors are highly willing to grant favourable formulary status to therapies that provide advantages for lung function or frequency of exacerbations over currently available therapies. However, they also indicate that if the drugs are priced at a premium to Spiriva, gains in efficacy will need to be substantial to secure reimbursement.


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