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News

Telik's small molecule proteasome inhibitor programme demonstrates anticancer activity

Telik : 22 August, 2008  (Company News)
Telik’s novel small molecule proteasome inhibitor programme has met a preclinical development milestone by demonstrating anticancer activity in preclinical models of human leukemia.
The proteasome is a cellular structure necessary for the growth and function of cancer cells and inhibition of the proteasome has been shown to promote cell cycle arrest and cancer cell death or apoptosis.

Bortezomib, an approved drug for the treatment of multiple myeloma, is based on this mechanism. Telik's proteasome inhibitors are orally active, non-peptide, non-boron based, and thus may lead to a drug candidate that might have advantages over Bortezomib and other proteasome inhibitors.

'The potentially favourable profile of these compounds was achieved through the use of our TRAP computational drug discovery technology,' said James Keck, PhD, vice president of Biology at Telik. 'We are currently conducting activities necessary to select a potential development candidate.'

Preliminary data on Telik's proteasome inhibitor programme was presented at the 2008 annual meeting of the American Association for Cancer Research.
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