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News

Thermo Fisher Scientific to unveil new high sensitivity LC-MS/MS system

Thermo Fisher Scientific Mass Spectrometry : 28 May, 2008  (New Product)
Thermo Fisher Scientific is to launch the Thermo Scientific TSQ Vantage at ASMS 2008 in Denver, USA.
A new LC-MS/MS system that delivers up to 10 times more sensitivity than any other triple quadrupole instrument on the market, it does not produce a commensurate increase in noise. New technical breakthroughs have given the TSQ Vantage unmatched signal-to-noise performance, providing better reproducibility and precision in the quantitative analysis of small molecules, biomolecules and peptides.

'The TSQ Vantage has delivered the highest sensitivity in the industry and we've done it without increasing the noise,' said Rohan Thakur, PhD, marketing director, Small Molecule Solutions, Thermo Fisher Scientific. 'This new system enables scientists working with small molecules, biomolecules or peptides to detect compounds at ultra low-quantitation levels and to do so reproducibly with great precision; doing anything less risks data integrity and potentially an entire drug study. The Thermo Scientific TSQ Vantage offers a huge competitive advantage for companies working to successfully move next-generation compounds, such as biosimilars, through regulatory review quickly and reliably.'

Many LC-MS/MS systems today claim high sensitivity, but can only deliver on that promise by sacrificing precision, specificity and reproducibility because of high chemical noise levels. The TSQ Vantage offers up to 10 times the signal-to-noise ratio when compared to the TSQ Quantum series and exceeds any other triple quadrupole instruments in the field. The instrument's performance is due to major technical innovations in ionization efficiency and ion transmission.

The Thermo Scientific TSQ Vantage's new S-Lens ion optics system uses a novel electrostatic field technology to capture virtually every ion and efficiently transfer it into the HyperQuad quadrupole mass analyser. The S-Lens design is a significant advance over high-pressure, skimmer-based ion source designs, as it eliminates mass discrimination and lowers the gas load on the expensive turbo-molecular pumps. This innovation keeps the ion optical path cleaner, longer, while maintaining sensitivity.

The TSQ Vantage will be demonstrated on the Thermo Scientific booth 41 at the 56th ASMS Conference on Mass Spectrometry and Allied Topics, in Denver, USA, June 1 to 5, 2008.
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