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Editor's Blog and Industry Comments

New research pinpoints the genetic basis of inflammatory disease

02 November, 2012
An international team of scientists is throwing new light on the genetic basis of the inflammatory bowel diseases (IBD) as the result of one of the largest studies of its kind ever conducted.


Dr John Rioux, researcher at the Montreal Heart Institute and Associate Professor of Medicine at the Universite de Montreal, is one of the researchers who have identified 71 genetic regions newly associated with inflammatory bowel disease (IBD), increasing the total number discovered to date to 163, in one of the largest studies of its kind. Also, the study points out that these regions showed a striking overlap with those implicated in autoimmune diseases and in immune deficiencies.  Even more surprising was the observation of a significant overlap with genetic regions controlling our response to microbial infections such as in the case of tuberculosis. The highlights are published in the scientific journal Nature.



The findings suggest that IBD results from overactive immune defence systems that evolved to fight off serious bacterial infections. In IBD, the body's immune system produces an ongoing inflammatory reaction in the intestinal tract that injures the intestinal wall, leading to diarrhoea and abdominal pain. IBD patients typically require lifelong treatment with drug therapy, and often need surgery to repair tissue damage caused by the disease.



Up until this point, researchers have been studying Crohn's disease and ulcerative colitis separately. Tes study was based on the fact that there seems to be a vast amount of genetic overlap between the two disorders.



In the first step of the study, the researchers conducted a 'meta-analysis' of 15 previous genomic studies of either Crohn's disease (CD) or ulcerative colitis (UC), the two most common forms of IBD, creating a large dataset that combined genetic information from some 34,000 individuals who took part in those studies. The results then formed part of a second meta-analysis that included data from new genome-wide scans of more than 41,000 DNA samples from CD/UC patients and healthy comparison subjects collected at 11 centers around the world by the International IBD Genetics Consortium.



"We have greatly expanded the map of genetic regions that are associated with IBD," agreed Dr John Rioux, Co-lead author of the study and Chair of the Consortium, with Jeffrey Barrett of the Wellcome Trust Sanger Institute in Cambridge, England, Lead author of the study. "Each of these regions only increases a person’s chance of developing IBD by a fraction of a per cent and even taken together they cannot tell us who will or will not develop the disease. But they each tell a small story about the biology of this disorder, and by combining them we find biological pathways that, if disrupted, can lead to IBD."



Dr Rioux and the international team of researchers also studied the activity of genes in their IBD regions in hundreds of different types of cells involved in the immune system. They found that certain cells tended to produce more of these IBD genes, including many that are involved in the body's first line defence against invasion. This illustrates that an immune response seems to be a major factor in IBD: when a bacterium is detected, these cells are not just activated, but become overactive.



"We see a genetic balancing act between defending against bacterial infection and attacking the body's own cells," said Dr Barrett. "Many of the regions we found are involved in sending out signals and responses to defend against bad bacteria. If these responses are over-activated, we found it can contribute to the inflammation that leads to IBD."



Nearly 100 scientists in 15 countries contributed to the new work, which "highlights the incredible power that working together in a large team can have," said Barrett. "This would not have been possible without the thousands of DNA samples from patients with these conditions assembled by the International IBD Genetics Consortium. Collectively, our findings have begun to uncover the biological mechanisms behind this disease."



Reference



Luke Jostins, Stephan Ripke, Rinse K Weersma, et al (2012). 'Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease'.


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